Countermeasures (iRED, ARED CEVIS, MEC, TVIS, T2, Periodic Fitness Evaluation, BP-ECG, HRM). Critical Readiness Review Increment 23 and 24

This slide presentation reviews attempts to counteract the effects of being in space. It includes information on the Resistive Exercise Device (RED), the Advanced Resistive Exercise Device (ARED), Cycle Ergometer with Vibration Isolation and Stabilization (CEVIS), Treadmill with Vibration Isolation and Stabilization (TVIS) and periodic fitness evaluation with specific information on BP/ECG, heart rate monitor 2 and data distribution

Advances in PET Detection of the Antitumor T Cell Response

Positron emission tomography (PET) is a powerful noninvasive imaging technique able to measure distinct biological processes in vivo by administration of a radiolabeled probe. Whole-body measurements track the probe accumulation providing a means to measure biological changes such as metabolism, cell location, or tumor burden. PET can also be applied to both preclinical and clinical studies providing three-dimensional information. For immunotherapies (in particular understanding T cell responses), PET can be utilized for spatial and longitudinal tracking of T lymphocytes. Although PET has been utilized clinically for over 30 years, the recent development of additional PET radiotracers have dramatically expanded the use of PET to detect endogenous or adoptively transferred T cells in vivo. Novel probes have identified changes in T cell quantity, location, and function. This has enabled investigators to track T cells outside of the circulation and in hematopoietic organs such as spleen, lymph nodes, and bone marrow, or within tumors. In this review, we cover advances in PET detection of the antitumor T cell response and areas of focus for future studies

Evaluation of the Federal Transit Administration’s Transit and Health Access Initiative: Case Highlights, Findings, and Recommendations

FTA’s Transit and Health Access Initiative provided funding for demonstration projects to test promising, replicable public transportation healthcare access solutions that support the “triple aim” of increased access to healthcare, improved health outcomes, and reduced healthcare costs. This paper highlights two compelling projects from the independent evaluation of the initiative, selected for their creative approaches and wealth of lessons learned. After in-depth case descriptions of these two projects, the authors present the overall findings and recommendations that emerged from the full evaluation effort. Overall, program participants credited the projects with significant improvements to their health. Some reported that, because of the projects, they were more active and independent, had more control over their lives, experienced less emotional hardship, and were better able to reach their goals. However, these results should be viewed in light of the caveats and limitations of relying on self-reported health data, which was often the best tool for programs unable to overcome the legal concerns surrounding health privacy laws and regulations

Factors influencing participation in cardiac rehabilitation programmes after referral and initial attendance: qualitative systematic review and meta-synthesis

Background:Greater participation in cardiac rehabilitation improves morbidity and mortality in people with coronary heart disease, but little is understood of patients' decisions to participate.Methods:To develop interventions aimed at increasing completion of programmes, we conducted a qualitative systematic review and meta-synthesis to explore the complex factors and processes influencing participation in cardiac rehabilitation programmes after referral and initial access. To be included in the review, studies had to contain a qualitative research component, population specific data on programme participation in adults >= 18 years, and be published 1995 as full articles or theses. Ten databases were searched (31 October 2011) using 100+ search terms.Results:Of 2264 citations identified, 62 studies were included involving: 1646 patients (57% female; mean age 64.2), 143 caregivers, and 79 professionals. Patients' participation was most strongly influenced by perceptions of the nature, suitability and scheduling of programmes, social comparisons made possible by programmes, and the degree to which programmes, providers, and programme users met expectations. Women's experiences of these factors rendered them less likely to complete. Comparatively, perceptions of programme benefits had little influence on participation.Conclusions:Factors reducing participation in programmes are varied but amenable to intervention. Participation should be viewed as a consumer behaviour' and interventions should mobilize family support, promote patient friendly' scheduling, and actively harness the social, identity-related, and experiential aspects of participation